Progesterone Receptor (Marker of Progestin Dependence) Antibody | LM11068 | Leading Biology

商品分类：单克隆抗体

产品概述：This MAb is specific to progesterone receptor and shows minimal cross-reaction with other members of the family. Progesterone receptor is expressed as two major isoforms, PR-A (81kDa) and PR-B (116kDa). Expression of PgR has been suggested to reflect a intact estrogen regulatory machinery and therefore, predict better clinical response to endocrine therapy than ER alone. It is excellent for immunohistochemical staining of formalin/paraffin tissues.

来源：Mouse

参考文献：Press M, et al. Steroids. 2002 Aug; 67(9):799-813. | Mote P, et al. J Clin Pathol., 2001; 54: 624-630

特异性：Human

别名：Progesterone receptor, PR, Nuclear receptor subfamily 3 group C member 3, PGR, NR3C3

简单描述：Mouse Monoclonal Progesterone Receptor (Marker of Progestin Dependence) Antibody. Validated for use in IHC. Clone: SPM566.

详情：FunctionThe steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation. Isoform 4: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.Cellular_LocationNucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases Isoform 4: Mitochondrion outer membrane

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