MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1) Antibody - Without BSA and Azide | LM10833 | Leading Biology

商品分类：单克隆抗体

产品概述：Mitogen-activated protein (MAP) kinase cascades are activated by various extracellular stimuli, including growth factors. The MEK kinases (also designated MAP kinase kinase kinases, MKKKs, MAP3Ks or MEKKs) phosphorylate and thereby activate the MEKs (also called MAP kinase kinases or MKKs), including ERK, JNK and p38. These activated MEKs in turn phosphorylate and activate the MAP kinases. The MEK kinases include Raf-1, Raf-B, Mos, MEK kinase-1, MEK kinase-2, MEK kinase-3, MEK kinase-4 and ASK 1 (MEK kinase- 5). MEK kinase-1 activates the ERK and c-Jun NH2-terminal kinase (JNK) pathways by phosphorylation of MAP2K1 and MAP2K4, and also activates the central protein kinases of the NFī?B pathway, CHUK and IKBKB. Additionally, MEK kinase-1 uses an E3 ligase through its PHD domain, a RING-finger-like structure, to target proteins for degradation through ubiquitination.

来源：Mouse

参考文献：Guan, K.L. 1994. The mitogen activated protein kinase signal transduction pathway: from the cell surface to the nucleus. Cell. Signal. 6: 581-589

特异性：Human

别名：Mitogen-activated protein kinase kinase kinase 1, 2.7.11.25, MAPK/ERK kinase kinase 1, MEK kinase 1, MEKK 1, MAP3K1, MAPKKK1, MEKK, MEKK1

简单描述：Mouse Monoclonal MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1) Antibody - Without BSA and Azide. Validated for use in WB, IHC, IF, FC. Clone: 2F6.

详情：FunctionComponent of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway.

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