CD47 / IAP (Integrin Associated Protein) Antibody - Without BSA and Azide | LM10433 | Leading Biology

商品分类：单克隆抗体

产品概述：This antibody reacts with Ig domain of CD47 protein. CD47, originally named integrin-associated protein (IAP), is a 50kDa protein containing five membrane-spanning sequences and a short cytoplasmic tail. CD47 plays a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. It is important in memory formation and synaptic plasticity in the hippocampus.ā CD47 may play a role in membrane transport and/or integrin dependent signal transduction.ā

来源：Mouse

参考文献：Edris B et. al. Proc Natl Acad Sci USA 109:6656-61 (2012). | Willingham SB et. al. Proc Natl Acad Sci USA 109:6662-7 (2012)

特异性：Human, Mouse

别名：Leukocyte surface antigen CD47, Antigenic surface determinant protein OA3, Integrin-associated protein, IAP, Protein MER6, CD47, CD47, MER6

简单描述：Mouse Monoclonal CD47 / IAP (Integrin Associated Protein) Antibody - Without BSA and Azide. Validated for use in IHC, IF, FC. Clone: IAP/964 + B6H12.2.

详情：FunctionHas a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection.Cellular_LocationCell membrane; Multi-pass membrane proteinTissue_LocationVery broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain

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