CD34 (Hematopoietic Stem Cell & Endothelial Marker) Antibody - Without BSA | LM10341 | Leading Biology

商品分类：单克隆抗体

产品概述：This MAb recognizes a single chain, transmembrane, heavily glycosylated protein of 90-120kDa, which is identified as CD34. On the basis of differential sensitivity to degradation by specific enzymes, epitopes of monoclonal antibodies to CD34 are classified intoāthree main categories, class I, class II and class III. It is a class II antibody whose epitope is resistant to neuraminidase but sensitive to glycoprotease and chymopapain.āCD34 expression is a hallmark for identifying pluripotent hematopoietic stem or progenitor cells. Its expression is gradually lost as lineage committed progenitors differentiate. CD34 is a marker of choice for staining blasts in acute myeloid leukemia. In addition, CD34 is expressed by soft tissue tumors, such as solitary fibrous tumor and gastrointestinal stromal tumor. Its expression is also found in vascular endothelium. Additionally, it appears that proliferating endothelial cells express this molecule more than the non-proliferating endothelial cells. Anti-CD34 labels > 85% of angiosarcoma and Kaposiā€?s sarcoma, but with a lower specificity.

来源：Mouse

存储溶液：200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.

参考文献：Ramani P; Bradley NJ; Fletcher CD. QBEND/10, a new monoclonal antibody to endothelium: assessment of its diagnostic utility in paraffin sections. Histopathology, 1990, 17:237-42

特异性：Human, Rhesus, Cynomolgus Monkey

别名：Hematopoietic progenitor cell antigen CD34, CD34, CD34

简单描述：Mouse Monoclonal CD34 (Hematopoietic Stem Cell & Endothelial Marker) Antibody - Without BSA. Validated for use in IHC-P, IF, FC. Clone: SPM123.

详情：FunctionPossible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.Cellular_LocationMembrane; Single-pass type I membrane proteinTissue_LocationSelectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues

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企业 QQ：3212874516、3198592576

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