Cyclin D1 (G1-Cyclin & Mantle Cell Marker)Mouse Monoclonal Antibody [Clone DCS-6] | LM11867 | Leading Biology

商品分类：单克隆抗体

靶点/蛋白：Human recombinant full length cyclin D1 protein

来源：Mouse

存储溶液：0.5ml at 100ug/ml with BSA and azide

参考文献：1. Lukas J, et. al. Oncogene, 1994, 9(3):707-18.2. Gillett C, et. al. Cancer Research, 1994, 54(7):1812-7.3. Bartkova J, et. al. Journal of Pathology, 1994, 172(3):237-45.

特异性：Human, Mouse, Rat, Monkey

别名：B cell CLL/lymphoma 1, B cell leukemia 1, B-cell lymphoma 1 protein, BCL-1 oncogene, CCND1 protein, CCND1/FSTL3 fusion gene, CCND1/IGHG1 fusion gene CCND1/IGLC1 fusion gene, CCND1/PTH fusion gene, cD1, Cyl 1, G1/S-specific cyclin-D1, Parathyroid adenomatosis 1, PRAD1 oncogene

简单描述：Mouse Monoclonal Cyclin D1 (G1-Cyclin & Mantle Cell Marker)Mouse Monoclonal Antibody [Clone DCS-6]. Validated for use in IF, FC. Clone: DCS-6.

详情：FunctionRegulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.Cellular_LocationNucleus. Cytoplasm. Membrane. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members

生物商城：http://www.annoron.com

办公电话：010-56256916

官方售后：400-965-8633

企业 QQ：3212874516、3198592576

地 址：北京大兴经济技术开发区(亦庄)同济中路7号兴盛国际A栋4层