GITR / Tnfrsf18 (mouse) Antibody - Without BSA and Azide | LM10758 | Leading Biology

商品分类：单克隆抗体

产品概述：GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25+āCD4+āTregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAPKs and NF-ī?B activation, and abrogate the inhibitory function ofāCD25+āCD4+āTregs. In vivoāactivation of GITR causes development of autoimmune diseases and restores the suppressed immune response.

来源：Rat

参考文献：Stephens GL, et al. 2004. J. Immunol. 173:5008. | Tone M, et al. 2003. Proc. Natl. Acad. Sci. USA 100:15059

特异性：Mouse

别名：Tumor necrosis factor receptor superfamily member 18, Glucocorticoid-induced TNFR-related protein, CD357, Tnfrsf18, Gitr

简单描述：Rat Monoclonal GITR / Tnfrsf18 (mouse) Antibody - Without BSA and Azide. Validated for use in IF, FC. Clone: DTA-1.

详情：FunctionReceptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway (By similarity).Cellular_LocationIsoform A: Cell membrane; Single-pass type I membrane protein Isoform C: Cell membrane; Single-pass type I membrane proteinTissue_LocationPreferentially expressed in activated T lymphocytes

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