CD34 (Hematopoietic Stem Cell & Endothelial Marker) Antibody - With BSA and Azide | LM10333 | Leading Biology

商品分类：单克隆抗体

产品概述：This antibody recognizes a carbohydrate epitope on a single chain, transmembrane, heavily glycosylated protein of 90-120kDa, which is identified as CD34 (VI international workshop on human differentiation antigens). Its expression is a hallmark for identifying pluripotent hematopoietic stem or progenitor cells. Its expression is gradually lost as lineage committed progenitors differentiate. CD34 is a marker of choice for staining blasts in acute myeloid leukemia. In addition, it is expressed by soft tissue tumors, such as solitary fibrous tumor and gastrointestinal stromal tumor. CD34 expression is also found in vascular endothelium. Additionally, proliferating endothelial cells overexpress this molecule than the non-proliferating endothelial cells. Anti-CD34 labels > 85% of angiosarcoma and Kaposi s sarcoma, but shows low specificity.

来源：Mouse

参考文献：Felshow DM et al. Blood 97:3768-3775 (2001). | Sato T et al. Blood 94:2548-2554 (1999). |

特异性：Human, Rat

别名：Hematopoietic progenitor cell antigen CD34, CD34, CD34

简单描述：Mouse Monoclonal CD34 (Hematopoietic Stem Cell & Endothelial Marker) Antibody - With BSA and Azide. Validated for use in WB, IHC, IF, FC. Clone: HPCA1/1171.

详情：FunctionPossible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.Cellular_LocationMembrane; Single-pass type I membrane proteinTissue_LocationSelectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues

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企业 QQ：3212874516、3198592576

地 址：北京大兴经济技术开发区(亦庄)同济中路7号兴盛国际A栋4层