Androgen Receptor (Marker of Androgen Dependence) Antibody - With BSA and Azide | LM10097 | Leading Biology

商品分类：单克隆抗体

产品概述：Recognizes a protein of 110kDa, which is identified as androgen receptor (AR). It reacts with full length, and the newly described A form of the receptor. It does not cross react with estrogen, progesterone, or glucocorticoid receptors. The expression of AR is reportedly inversely correlated with histologic grade i.e. well differentiated prostate tumors show higher expression than the poorly differentiated tumors. In prostate cancer, AR has been proposed, as a marker of hormone-responsiveness and thus it may be useful in identifying patients likely to benefit from anti-androgen therapy. Anti-androgen receptor has been useful clinically in differentiating morpheaform basal cell carcinoma (mBCC) from desmoplastic trichoepithelioma (DTE) in the skin.āThis MAb is superb for staining of formalin/paraffin tissues.

来源：Mouse

参考文献：J?nne OA, et al. Androgen receptor and mechanism of androgen action. Ann Med 1993; 25:8

特异性：Human

别名：Androgen receptor, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4, AR, DHTR, NR3C4

简单描述：Mouse Monoclonal Androgen Receptor (Marker of Androgen Dependence) Antibody - With BSA and Azide. Validated for use in IHC, IF. Clone: AR441 + DHTR/882.

详情：FunctionSteroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.Cellular_LocationNucleus. Cytoplasm. Note=Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence of GNB2L1Tissue_LocationIsoform 2 is mainly expressed in heart and skeletal muscle.

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