Human CD96 / TACTILE Protein, Mouse IgG2a Fc Tag_详细资料

产品信息 供应商： ACROBiosystems 英文名： Human CD96 / TACTILE Protein, Mouse IgG2a Fc Tag 保存条件： -20 规格： 100ug/1mg 规格： 100ug 产品价格： ¥3500.0 规格： 1mg 产品价格： ¥23100.0 内毒素: Less than 1.0 EU per μg by the LAL method. 纯度: >85% as determined by SDS-PAGE. 活性: Immobilized Human CD96, mouse IgG2a Fc tag (Cat. No. TAE-H5252) at 2 μg/mL (100 μL/well) can bind Human CD155, Fc Tag (Cat. No. CD5-H5251) with a linear range of 0.2-1.25 μg/mL (QC tested). 产品背景: The progression of pancreatic cancer (PC) is significantly associated with tumor immune escape, which may be associated with nature killer (NK) cell dysfunction. CD226, CD96, and TIGIT, which share the ligand CD155, play important roles in the regulation of NK cell function. The present study was conducted to investigate the roles of these molecules in NK cells from PC patients. TIGIT and CD96 together with the co-stimulatory receptor CD226 form a pathway that is analogous to the CD28/CTLA-4 pathway, in which shared ligands and differential receptor:ligand affinities fine-tune the immune response. Although the roles of TIGIT and CD96 as immune checkpoint receptors in T cell and natural killer cell biology are just beginning to be uncovered, accumulating data support the targeting of these receptors for improving anti-tumor immune responses. A clear understanding of the immune cell populations regulated by TIGIT and CD96 is key to the design of immunotherapies that target these receptors in combination with other existing immune checkpoint blockade therapies. The dysfunction of CD96 may trigger C syndrome: A syndrome characterized by trigonocephaly, severe mental retardation, hypotonia, variable cardiac defects, redundant skin, and dysmorphic facial features, including upslanted palpebral fissures, epicanthal folds, depressed nasal bridge, and low-set, posteriorly rotated ears. 产品描述: Human CD96, mouse IgG2a Fc tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 85%.SDS-PAGE 因为难以在供应系统上进行数据同步，所以了解更多产品规格及产品数据，请移步： http://www.acrobiosystems.cn/P1154-Human_CD96_%7C_TACTILE_Protein_Mouse_IgG2a_Fc_Tag.html 订购方式 您可以通过官网查看产品信息、拨打订购电话、发送邮件或者直接点索取报价等方式进行订购，我们的客服将会竭诚为您服务。 电话：400-682-2521 网址：http://www.acrobiosystems.cn 邮箱：order.cn@acrobiosystems.com（订购及产品咨询） 邮箱：techsupport@acrobiosystems.com（技术支持）(请咨询时注明是在丁香通看到产品信息 温馨提示：不可用于临床ZL。

规格：	100ug	产品价格：	¥3500.0
规格：	1mg	产品价格：	¥23100.0

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Human CD96 / TACTILE Protein, Mouse IgG2a Fc Tag

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