重组人METAP1(甲硫氨酰氨肽酶1)(甲硫氨酸氨肽酶1)批发

特别声明：本产品及我公司所售其他产品均为科研类试剂产品，严禁用于药物、YL及其他非科研用途。

北京百奥莱博主要从事生物试剂的生产和销*(代"售")，产品线涵盖重组人METAP1(甲硫*酰*肽酶1)(甲硫*酸*肽酶1)批发在内的分子生物学试剂产品，还包括PCR及荧光定量PCR、核酸提取试剂盒类、样本核酸保护试剂、核酸提取、克隆与转化、蛋白纯化、蛋白检测、免疫组化、细胞凋亡与抗体等。

名称：重组人METAP1(甲硫*酰*肽酶1)(甲硫*酸*肽酶1)批发
规格：10μg|50μg|500μg|1mg
产地：国产|进口
编号：JN1612
品Pai：百奥莱博
英文名：Recombinant Human Methionine Aminopeptidase 1
本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Met1-Phe386表达纯化得来。

METAP1质量控制：＞95%(还原性SDS-PAGE)

METAP1制剂：液体

METAP1保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于METAP1：
Methionine Aminopeptidase 1 is a member of the M24 family of metalloproteases. METAP1 plays an important role in G(2)/M phase regulation of the cell cycle and may serve as a promising target for the discovery and development of new anticancer agents.METAP1 and METAP2 have different substrate specificity due to the differences in both size and shape of the active sites. The proteolytic removal of N-terminal methionine from nascent peptides is catalyzed by a family of enzymes known as methionine aminopeptidases (MetAPs) and is essential for cell growth. Inhibition of METAPs provides a novel strategy in developing anti-cancer drugs.

我公司的重组人METAP1(甲硫*酰*肽酶1)(甲硫*酸*肽酶1)批发，性价比高，货期短，送货上门，欢迎您来电咨询购买，另外，我公司还生产供应销*(代"售")下列产品：
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重组人METAP1(甲硫*酰*肽酶1)(甲硫*酸*肽酶1)批发关键词：重组人METAP1,重组人甲硫*酰*肽酶1,重组人METAP1蛋白,JN1612,重组人甲硫*酸*肽酶1

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重组人METAP1(甲硫*酰*肽酶1)(甲硫*酸*肽酶1)批发关键词：重组人METAP1,重组人甲硫*酰*肽酶1,重组人METAP1蛋白,JN1612,重组人甲硫*酸*肽酶1


·*苄青霉素溶液(50mg/ml)
编号：JN0117
规格：1ml×10

·重组小鼠IL-36b(IL-1F8)
编号：JN1398
英文名称：Recombinant Mouse Interleukin-36 beta
规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Ser31-Lys183表达纯化得来。

IL-36b/IL-1F8质量控制：＞95%(还原性SDS-PAGE)

IL-36b/IL-1F8制剂：冻干品

IL-36b/IL-1F8保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

IL-36b/IL-1F8复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于IL-36b/IL-1F8：
Mouse Interleukin 36 beta (IL-36B)is a member of the IL-1 family of proteins. It is a cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. IL-36B is synthesized in several cells including resting and activated monocytes, and B cells. The receptor for IL-36 beta is thought to be a combination of IL-1 Rrp2 and IL-1 RAcP. Interleukin 36 beta is one part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Interleukin 36 beta are involved in a number of fundamental biological processes such as stimulating production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes, inducing expression of a number of antimicrobial peptides including beta-defensin 4 and beta-defensin 103 as well as a number of matrix metalloproteases , inducing the production of proinflammatory cytokines in bone marrow-derived dendritic cells (BMDCs), including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23, and activating p38 MAPK phosphorylation in BMDCs.Moreover, interleukin 36 beta may be involved in skin inflammatory response by acting on keratinocytes, dendritic cells, and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. It plays an important role in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II and inducing the production of IFN-gamma, IL-4 and IL-17 by T helper 1 (Th1) cells, cultured CD4+ T cells and splenocytes.

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