Cabozantinib (XL184, BMS-907351)卡博替尼

ID：T2586

PURITY：1

Formula：C28H24FN3O5

MolWt：501.5

Appearance：白色粉末

Solubility：G4Soluble in DMSO

Bioactivity：Cabozantinib (XL184, BMS-907351) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM in cell-free assays, respectively.

Status：

Pathways：Tyrosine Kinase/Adaptors

Target：VEGFR inhibitor

Receptor：VEGFR1,2,3