胆汁酸全谱定量分析

胆汁酸全谱分析

技术亮点：
1) 检测胆汁酸种类丰富：包含胆酸、鹅去氧胆酸、熊去氧胆酸、脱氧胆酸、石胆酸及其甘氨酸和牛磺酸、葡萄糖醛酸结合型等70+种胆汁酸JD定性定量检测；
2) 确保多种同分异构体均获得较好的分离，并采用10个具有代表性的同位素胆汁酸作为内标校正，显著提高定性定量检测的准确性。

       胆汁酸分析检测流程示意图

分析样本类型：

1. 主要包括血清、粪便、尿液、组织及肠内容物等等。
2. 样本ZD需求量：血样、胆汁等仅需10uL，组织、粪便等20mg即可。

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使用本方法所发表的代表文献：

1) Guoxiang Xie, Xiaoning Wang, et al. Dysregulated hepatic bile acids collaboratively promote liver Carcinogenesis. Int. J. Cancer, 2016, 139(8): 1764-75. (IF=5.5)

2) Xiaoning Wang, Guoxiang Xie, et al. Serum Bile Acids Are Associated with Pathological Progression of Hepatitis B-induced Cirrhosis. J Proteome Res, 2016, 15(4), 1126-34. (IF=4.2, Citations: 3)

3) Guoxiang Xie, Yixing Wang, et al. Profiling of Serum Bile Acids in a Healthy Chinese Population Using UPLC-MS/MS. J Proteome Res, 2015, 14(2): 850-59. (IF=4.2, Citations: 3)

4) Guoxiang Xie, Wei Zhong, et al. Alteration of Bile Acid Metabolism in the Rat Induced by Chronic Ethanol Consumption. FASEB J, 2013, 27(9): 3583-93. (IF=5.3, Citations: 22)

5) Haoyong Yu, Yan Ni, et al. Chenodeoxycholic Acid as a Potential Prognostic Marker for Roux-en-Y Gastric Bypass in Chinese Obese Patients. J Clin Endocr Metab, 2015, 100 (11), 4222-30. (IF=5.5, Citations: 3)