BCR/ABL Translocation, Dual Fusion Probe

The presence of the Philadelphia chromosome, produced as a result of the Philadelphia translocation t(9;22)(q34;q11), has important diagnostic and prognostic implications in a number of Haematological disorders. The abnormality is characteristic of CML (found in around 90% of cases) but represents a significant abnormality in 30% of adult and 2 to 10% of childhood ALL cases. This rearrangement is also seen in rare cases of AML. The stereotypic translocation fuses the ABL1 proto-oncogene to the BCR gene, giving rise to the BCR/ABL1 fusion gene, which encodes for tyrosine kinase. Know more at: http://www.creative-bioarray.com/BCR-ABL-Translocation,-Dual-Fusion-Probe-FHPC-020-item-4661.htm