ActiveMax® Recombinant Human TGF-Beta 1 / TGFB1

内毒素:
Less than 1.0 EU per μg by the LAL method.

纯度:
>95% as determined by SDS-PAGE.

活性:
The bio-activity was determined by its ability to inhibit IL-4 induced HT-2 cell proliferation. The <0.05 ng/mL, corresponding to a specific activity of >20000000 Unit/mg

产品背景:
Transforming growth factor beta 1 ( TGFB1) is also known as TGF-β1, CED, DPD1, TGFB. is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The TGFB1 protein helps control the growth and division (proliferation) of cells, the process by which cells mature to carry out specific functions (differentiation), cell movement (motility), and the self-destruction of cells (apoptosis). The TGFB1 protein is found throughout the body and plays a role in development before birth, the formation of blood vessels, the regulation of muscle tissue and body fat development, wound healing, and immune system function. TGFB1 is particularly abundant in tissues that make up the skeleton, where it helps regulate bone growth, and in the intricate lattice that forms in the spaces between cells (the extracellular matrix). Within cells, this protein is turned off (inactive) until it receives a chemical signal to become active. TGFB1 plays an important role in controlling the immune system, and shows different activities on different types of cell, or cells at different developmental stages. Most immune cells (or leukocytes) secrete TGFB1. TGFB1 has been shown to interact with TGF beta receptor 1, LTBP1, YWHAE, EIF3I and Decorin.

产品描述:
ActiveMax® Human TGF-Beta 1 contains no "tag", and has a calculated MW of 12.8 kDa (monomer). The predicted N-terminus is Ala 279. the reducing (R) protein migrates as 13 kDa (monomer), and the non-reducing (NR) protein migrates as 25 kDa (homodimer) in SDS-PAGE.