Polycomb & Trithorax复合物靶基因PCR基因芯片Polycomb & Trithorax Target Genes PCR Array

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Polycomb & Trithorax Target Genes PCR Array

Polycomb & Trithorax复合物靶基因PCR基因芯片 
 

Product	Species	Technology	Cat. No.
Polycomb & Trithorax Target Genes PCR Array	Human	Gene Expression	PAHS-505Z
Polycomb & Trithorax Target Genes PCR Array	Mouse	Gene Expression	PAMM-505Z
Polycomb & Trithorax Target Genes PCR Array	Rat	Gene Expression	PARN-505Z

Polycomb & Trithorax Target Genes RT² Profiler™ PCR Array profiles the expression of 84 key genes targeted by the Polycomb and Trithorax complexes of chromatin modification enzymes and remodeling factors. The polycomb and trithorax complexes maintain epigenetic control of cell type specific gene expression patterns important for cellular identity via histone modification. The polycomb complex causes transcriptional repression, while the trithorax complex reverses that effect to maintain an active state of transcription. Polycomb and trithorax complex activity controls the proper differentiation of induced and embryonic pluripotent stem cells, as confirmed via expression changes of identified target genes reflected in the content of this array. Dysregulation of polycomb and trithorax complex activity promotes oncogenesis by causing inappropriate expression of cell identity and differentiation genes, making the study of target gene expression important to cancer research. Using real-time PCR, your research study can easily and reliably analyze the expression of a focused panel of genes targeted by polycomb and trithorax complexes with this array.
Polycomb & Trithorax复合物靶基因PCR基因芯片可以同时检测被Polycomb & Trithorax复合物调控的84个关键基因的表达。Polycomb & Trithorax复合物通过组蛋白修饰进行表观遗传调控，调节细胞类型特异性基因的表达，对维持细胞特征非常重要。Polycomb & Trithorax复合物的活性控制着胚胎多能干细胞分化机制的诱导。它们活性的失调造成细胞特性改变，细胞分化和增殖基因的错误表达，并促成肿瘤发生。利用实时定量PCR，研究者可以方便并且可信地研究对被Polycomb和Trithorax复合物调控的重要靶基因进行同时检测
Cellular Mechanisms:
Differentiation:BMP2, CADM1 (TSLC1), CCND2, CHST11, DHH, DKK1, EFNB1, EPHA4, EPHB3, FOXA2 (HNF3B), GATA2, GATA6, HAND1, HES1, IL6R, IRX3, JUN, KLF4, OTX2, PDGFRA, PMP22, RARB, SALL1, SOX17, THPO, TRIM10, TRIM15, UCP1, WNT5A.
Signal TransductionBMP2, CDC42EP1, CDKN1A (p21CIP1/WAF1), CHST11, CXCL16, ACKR3, DKK1, DKK2, EPHA4, EPHB3, GAS6, HES1, HEY1, IGFBP1, IL6R, IRS4, JUN, OTX2, PDGFRA, PRKCH, PRKG2, PTPRA, RARB, RASD1, RASSF1, SMOC2, SOX17, TACSTD2, TCF7, TNFRSF19, WNT5A.
Cell Cycle:BMP2, CCND2, CDKN1A (p21CIP1/WAF1), DHH, ESX1, G0S2, JUN, RASSF1.
Apoptosis:CADM1 (TSLC1), CDKN1A (p21CIP1/WAF1), CHST11, GATA6, IL6R, JUN, RARB, RYBP, SERPINB2 (PAI-2), TNFRSF19.
Extracellular Matrix Organization:CTSA, LOX, PDGFRA, TIMP3.
Chromatin Modification:BMI1 (PCGF4), CBX8, HMGN2, RBBP7.
Other:CDH11, CYP1B1, DGAT2, FAM65A, HS3ST1, HS6ST2, MGLL, MYO5B, NID2, NPTX1, THBD, TMEM66, USP3, VSNL1.
Cellular Functions:
Transcription Factors:ATF3, ESX1, FOXA2 (HNF3B), GATA2, GATA3, GATA4, GATA6, HAND1, HEY1, HOXA10, HOXA5, IRX3, JUN, KLF4, MEIS2, OTX2, RARB, SALL1, SATB1, TRIM15, TSHZ1.
Transporters:KCNA1, SLC30A4, SLC34A2, TRPM3, UCP