致癌基因和肿瘤YZ基因384 hcqBiomarker拷贝数PCR芯片Oncogenes & Tumor Suppressor Genes 384HC qBiomarker Copy Number PCR Arrays

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Oncogenes & Tumor Suppressor Genes Copy Number

PCR Arrays

致癌基因和肿瘤YZ基因384 hcqBiomarker拷贝数PCR芯片
 

Product	Species	Technology	Cat. No.
Oncogenes & Tumor Suppressor Genes 384HC qBiomarker Copy Number PCR Arrays	Human	Copy Number	VAHS-3002Z

 
The Human Oncogenes & Tumor Suppressor Genes 384HC qBiomarker Copy Number PCR Array profiles the copy number of 95 genes reported to undergo frequent genomic alterations in human tumor DNA. Copy number alterations (CNA) are changes in DNA copy number that occur frequently in cancer. Identifying and profiling recurring DNA copy number changes in cancer may reveal CNA that can serve as new biomarkers and novel therapeutic targets for different subgroups. The genes on the array encode transcription factors, growth factors and their receptors, and kinases and phosphatases that regulate processes such as the cell cycle, cellular senescence, apoptosis, metastasis, drug metabolism, drug resistance, and p53, PI3K-AKT, growth factor and WNT signaling. Genes were chosen from the most frequently amplified or deleted genes relevant to oncogenic pathways and cancer biology based on the primary literature and public databases. This array may serve as a useful tool to help classify cancer samples by genotype and help verify gastric cancer phenotypic biomarkers. The array analyzes each gene in each sample in quadruplicate and includes a stable multi-copy reference assay for accurate copy number determination via appropriate DNA input normalization. The simplicity of the product format and operating procedure allow routine and reliable copy number profiling in any research laboratory with access to a real-time PCR instrument.
The qBiomarker Copy Number PCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention, or treatment of a disease.
96-well Plate, 384-well (4 × 96) Plate, and 100-well Disc formats are available.
 
致癌基因和肿瘤YZ基因384 hcqBiomarker拷贝数PCR芯片用于研究在人类肿瘤中发生频繁突变的95个基因的拷贝数.拷贝数突变(CNA)DNA拷贝数的改变在癌症中经常发生。鉴定和分析癌症中重复DNA拷贝数的改变，可能揭示CAN在不同子组可作为新的生物标记和新颖的ZL靶标。该芯片上的基因编码转录因子、生长因子及其受体，以及调节细胞周期,细胞衰老、凋亡、转移、药物代谢、药物耐药性,p53,PI3K-AKT、生长因子和WNT信号通路等过程的激酶和磷酸酶。基于主要文献和公共数据库，该芯片上的基因选自致癌途径和癌症生物学上相关的最频繁扩增或缺失的基因。这个芯片可作为帮助癌症样本基因型分类并验证癌症表型生物标记的有效工具。这个芯片可以使每个基因在每个样本中有四个重复，同时包含一个稳定的多拷贝参考实验，通过适当的DNA插入标准化精确检测拷贝数。简单的产品模式和操作程序让任何一个具备实时定量PCR仪的实验室都可进行常规可靠的拷贝数检测。
qBiomarker拷贝数PCR芯片用于分子生物学应用。本产品不用于疾病的诊断、预防和ZL。
提供96孔板，384 -(4×96)板，和100 孔。
 
 
AKT / PI-3-Kinase Signaling:AKT1, AKT2, PIK3CA.
Apoptosis:BCL2L1.
Cell Cycle:APC, AURKA, CCND1, CCND2, CCND3, CCNE1, CDK4, CDK6, CDKN1B, CDKN2A, CDKN2B, CDKN2C, FBXW7, MDM2, SKP2.
Cytoskeleton Regulators:CDC42, GRB7, NF1, NF2, PAK1, PTK2, STK11, TRIO.
DNA Damage & Repair:BRCA2, TOP2A.
Drug Metabolism:ABCB1, ATP7B.
ECM & Cell Adhesion:CD44, CDH1, CTNNB1, TNC.
Epigenetic Factors:DNMT3B, EZH2.
G-Protein Signaling:CDC42, GNAS, HRAS, KRAS, NRAS, PAK1, RAF1, SHC1.
Growth Factors:FGF1, FGF3, IL6, NOTCH3, TGFB2, VEGFA.
Metabolism:FHIT, MTAP, PDK1.
PhosphatasesFHIT, PTEN, PTPN1.
Receptor Tyrosine Kinases:ALK, EGFR, ERBB2, ERBB3, FGFR1, FGFR2, FGR, IGF1R, IGF2R, KDR, KIT, MET, PDGFRA, PDGFRB.
Telomeres & Telomerase:TERC, TERT
 

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