R-Phycoerytrhin Glycogen phosphorylase BB antibody conjugate (8G7)

Glycogen phosphorylase (GP), is an enzyme that plays an essential role in glycogenolysis (which is the regulation of carbohydrate metabolism by glycogen mobilization). Three isoenzymes of GP have been identified that are encoded by different genes. The isoenzymes are named according to the tissue in which they are predominantly found: brain (BB), skeletal muscle (MM) and liver (LL). GP isoenzymes BB and MM are also found in the heart, with BB being mainly located in the myocardium. In cardiomyocytes, GP-BB is associated with glycogen and the sarcoplasmic reticulum. Studies suggest that following myocardial injury GP-BB is rapidly released from the sarcoplasmic reticulum into the cytoplasm, and then as a soluble form into the circulation. GPBB is not a cardiac specific marker but can be detected in the plasma soon after the onset of chest pain. As a result, GP-BB has been reported to be a useful as an early biomarker for myocardial ischemia and for acute coronary syndromes including acute myocardial infarction and unstable angina.