Recombinant Influenza A [A/Shanghai/2/2013(H7N9)] Hemagglutinin (HA), Fc Tag

内毒素:
Less than 1.0 EU per μg by the LAL method.

纯度:
>95% as determined by SDS-PAGE.

活性:


产品背景:
Influenza, commonly known as "the flu", is an infectious disease of birds and mammals caused by RNA viruses of the family Orthomyxoviridae, the influenza viruses. The virus is divided into three main types (Influenzavirus A, Influenzavirus B, and Influenzavirus C), which are distinguished by differences in two major internal proteins (hemagglutinin (HA) and neuraminidase (NA), which are the most important targets for the immune system. The type A viruses are the most virulent human pathogens among the three influenza types and cause the most severe disease. The serotypes that have been confirmed in humans, ordered by the number of known human pandemic deaths, are: H1N1, H2N2, H3N2, H5N1, H7N7, H1N2, H9N2, H7N2, H7N3, H10N7, H7N9. H7N9 is a serotype of the species Influenzavirus A (avian influenza virus or bird flu virus). H7 normally circulates amongst avian populations with some variants known to occasionally infect humans. An H7N9 virus was first reported to have infected humans in 2013 in China.

产品描述:
Influenza A [A/Shanghai/2/2013(H7N9)] HA, Fc Tag is fused with a human IgG1 Fc tag at the C-terminus, and has a calculated MW of 84.5 kDa. The predicted N-terminus is Asp 19. The reducing (R) protein migrates as 110-120 kDa in SDS-PAGE due to glycosylation.