Cynomolgus CD3 epsilon Protein

内毒素:
Less than 1.0 EU per μg by the LAL method.

纯度:
>97% as determined by SDS-PAGE.

活性:


产品背景:
CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.

产品描述:
Cynomolgus CD3 epsilon, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 11.7 kDa. The predicted N-terminus is Gln 22. The reducing (R) protein migrates as 18-20 kDa in SDS-PAGE due to glycosylation.