BLMH / Bleomycin Hydrolase抗体产品信息
免疫原 :
Recombinant Human BLMH / Bleomycin Hydrolase protein (Catalog#11333-H07E)
Antibody Type : Rabbit Polyclonal Antibody ( Antibody Purification Platform )
抗体宿主 :
Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 :
Produced in rabbits immunized with purified, recombinant Human BLMH / Bleomycin Hydrolase (rh BLMH / Bleomycin Hydrolase; Catalog#11333-H07E; NP_000377.1; Ser 2-Glu 455). BLMH / Bleomycin Hydrolase specific IgG was purified by Human BLMH / Bleomycin Hydrolase affinity chromatography.
BLMH / Bleomycin Hydrolase抗体 Background
Bleomycin hydrolase, also known as BLM hydrolase and BLMH, is cytoplasm protein which belongs to thepeptidase C1 family. BLM hydrolase / BLMH is a cytoplasmic cysteine peptidase that is highly conserved through evolution. The only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. It catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity. BLM hydrolase / BLMH contains the signature active site residues of the cysteine protease papain superfamily. BLM hydrolase / BLMH inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred. BLM-induced death and has an important role in neonatal survival and in maintaining epidermal integrity. Mice lacking BLMH exhibited variably penetrant tail dermatitis that resembled rodent ringtail. The histopathology of the tail dermatitis was similar to skin lesions in humans with pellagra, necrolytic migratory erythema, and acrodermatitis enteropathica.
BLMH / Bleomycin Hydrolase抗体相关产品如下:
hz-7797R DUSP13双特异性磷酸酶13抗体
hz-10015R DIM-7DIM-7蛋白抗体
hz-6697R DICER1核糖核酸酶Dicer抗体
hz-5834R DCBLD2内皮细胞和平滑肌细胞衍生的神经纤毛蛋白抗体
hz-2835R ASB2含锚蛋白重复序列-细胞因子信号YZ物盒蛋白家族2抗体
hz-6641R DNA Ligase 1DNA连接酶1抗体
hz-5910R DHHDHH蛋白抗体
hz-6608R DDCTD型多巴色素脱羧酶
hz-6166R DNA polymerase alphaDNA聚合酶α抗体
hz-9665R MREGMREG蛋白抗体
hz-6163R DIRAS1RAS相关抑细胞生长蛋白1抗体
hz-9667R DENND2CMAP激酶激活死亡域蛋白2C抗体
hz-3902R Dio3甲状腺素5'脱碘酶3抗体
hz-3624R Delta Opioid ReceptorD型受体抗体
hz-6377R Deformed Epidermal Autoregulatory Factor 1畸形表皮自调节因子1抗体
hz-12149R DBX2脑发育同源蛋白2抗体
hz-6891R DMTF1周期素D相互作用蛋白1抗体
hz-12286R DDX3Y精子发育相关蛋白DDX3Y抗体
hz-13007R DKC1核仁蛋白NAP57抗体
hz-13008R DLSTDLST蛋白抗体
hz-12953R Desmoplakin I+II桥粒斑蛋白1+2抗体
hz-10152R Desmoglein 2桥粒芯糖蛋白2抗体
hz-12245R DAZL生殖细胞发育相关蛋白DAZL抗体
hz-7416R DNA polymerase deltaDNA聚合酶γ抗体
hz-7352R DR5死亡受体5抗体
hz-13744R Desmoglein 4桥粒芯糖蛋白4抗体
hz-10522R DAP12自然杀伤激活受体相关蛋白DAP12抗体
hz-12630R DAP12自然杀伤激活受体相关蛋白DAP12抗体
hz-13609R DAZ4无精症缺失基因4抗体
hz-13595R Dppa4多能发育相关基因4抗体
hz-13594R DZIP1锌指蛋白DZIP1抗体
hz-7345R DLL1Notch信号通路Delta样配体1抗体
hz-6467R Dlx1同源转录因子DLX1抗体
hz-4290R CDC37Hsp90辅助伴侣分子CDC37抗体
hz-6718R Dystrophin肌营养不良蛋白抗体
hz-3577R Dematin金属离子转运体1抗体
hz-2162R DKK1抑癌蛋白DKK1抗体
hz-11549R Dispatched膜转运蛋白DISPA抗体
hz-13003R DIRAS2DIRAS2蛋白抗体
hz-0993R DDX58DDX58抗体
hz-3597R DDX4DDX4抗体
hz-1672R Duck plague virus鸭瘟病毒DPV抗体
hz-3514R D-DIMER交联纤维蛋白二聚体抗体
hz-5835R Drebrin脑发育调节蛋白抗体
hz-7648R DFFBDNA断裂因子抗体(蛋白酶激活脱氧核糖核酸酶)
hz-7653R DNase gamma脱氧核糖核酸酶γ抗体
hz-7659R DATF1死亡相关转录因子1抗体
hz-7651R DNase I脱氧核糖核酸酶1抗体
hz-7652R DNase II脱氧核糖核酸酶2抗体
hz-6800R DAD1细胞死亡防卫蛋白1抗体
hz-7592R DARCDuffy血型趋化因子受体抗体