Neuropilin 2 / NRP2抗体

Neuropilin 2 / NRP2抗体产品信息免疫原 :  Recombinant Human Neuropilin 2 / NRP2 protein (Catalog#10695-H08H)
 
Reagents :  PE-conjugated mouse monoclonal antibody 
Clone ID : 03
抗体宿主 : Mouse IgG1
Concentration : 20 μl/Test, 0.1 mg/ml
缓冲液 : Aqueous solution containing 0.5% BSA and 0.09% sodium azide 
制备方法 :  This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Neuropilin 2 / NRP2 (rh Neuropilin 2 / NRP2; Catalog#10695-H08H; NP_003863.2; Met 1-Tyr 855) and conjugated with PE under optimum conditions, the unreacted PE was removed.
Neuropilin 2 / NRP2抗体 Background
Neuropilin-2 (NRP-2) which is related to NRP-1, is a type I transmembrane glycoprotein and has the structure characteristic with five main extracellular domains: two complement binding (CUB) domains, two coagulation factor V/VIII homology domains, and a MAM (meprin, tyrosine phosphatase domain) region. NRP-2 is a receptor capable of binding two disparate ligands, classⅢ semaphorins (SEMA) and vascular endothelial growth factors (VEGF), and thus regulates two diverse systems by activating cellular signaling pathways via interacting with other cell surface receptors such as VEGF receptors and plexins. NRP-2 is well known for its role in facilitating axonal guidance during the development of the neuronal system, and additionally, it is also expressed in vascular endothelial cells and lymphatic endothelium where it affects proliferation, migration, angiogenesis, as well as formation of small lymphatic vessels and capillaries. Recent study has identified NRP-2 as a polysialylated protein expressed in human dendritic cells and modulates DC-T cell Interactions. Nearly all tumor cells express neuropilins and NRP-2 is predominantly expressed in neuronal tumors and melanomas. Furthermore, it is suggested that as the specific ligand for NRP-2, SEMA 3F inhibits tumor angiogenesis and metastasis.
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