Anti-IL-28R白细胞介素28受体抗体

本公司提供科研IL-28R白细胞介素28受体抗体，抗体质量可靠，订购IL-28R白细胞介素28受体抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：白细胞介素28受体抗体
英文名称：Anti-IL-28R
货号：bs-11137R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 55kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, pig, cow, Rb
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：IL-28R is a 535 amino acid protein encoded by the human gene IL28RA. IL-28R belongs to the type II cytokine receptor family and contains 1 fibronectin type-III domain. It is a single-pass type I membrane protein found as a heterodimer with IL-10RB. This is a receptor for a small family of structurally-related cytokines that, like IFNs, are known to induce antiviral activity. The expression of IFN-I (IL-28) mRNA is inducible by viral infection in several cell lines. The receptor complex (IL-28R) that is utilized by all three IFN-l proteins for signaling is composed of two subunits, a receptor designated IL-28R and IL-10R2. Both receptor chains are constitutively expressed on a wide variety of human cell lines and tissues and signal through the Jak-STAT (Janus kinases-signal transducers and activators of transcription) pathway.Function : IL28RA is a class II cytokine receptor that interacts with IL10RB to bind IL28A, IL28B, and IL29, which are related to type I interferons. These ligands play a critical role in response to microbial challenge and activate the JAK/STAT signaling system. It heterodimers with IL10RB. There are 4 isoforms as result of alternative splicing. It is widely expressed. IL28RA belongs to the type II cytokine receptor family, and contains 1 fibronectin type III domain.Subunit : Heterodimer with IL10RB.Subcellular Location : Membrane; Single-pass type I membrane proteinTissue Specificity : Widely expressed.Similarity : Belongs to the type II cytokine receptor family.Contains 1 fibronectin type-III domain.