Anti-PDX1胰岛素促进因子抗体（胰十二指肠同源异型盒蛋白）

本公司提供科研PDX1胰岛素促进因子抗体（胰十二指肠同源异型盒蛋白），抗体质量可靠，订购PDX1胰岛素促进因子抗体（胰十二指肠同源异型盒蛋白）请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：胰岛素促进因子抗体（胰十二指肠同源异型盒蛋白）
英文名称：Anti-PDX1
货号：bs-0923R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 30kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, chk
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell. Insulin promoter factor 1 is an islet-specific protein that activates transcription of the insulin andsomatostatin genes. It is a key regulator of islet peptide hormone expressionn and also plays an essential role in pancreatic development. Mutations in this gene may be involved in several disorders of the pancreas or in diabetes mellitus. Belongs to the Antp homeobox family. IPF1/XlHbox-8 subfamily. & Contains 1 homeobox DNA-binding domain. Subcellular Location: Nucleus. Tissue Specificity: Duodenum and pancreas.Function : Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.Subunit : Interacts with the basic helix-loop-helix domains of TCF3(E47) and NEUROD1 and with HMG-I(Y). Interacts with SPOP (By similarity). Interacts with the methyltransferase SETD7.Subcellular Location : Nucleus.Tissue Specificity : Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells).Post-translational modifications : Phosphorylated by the SAPK2 pathway at high intracellular glucose concentration.DISEASE : Defects in PDX1 are a cause of pancreatic agenesis (PAC)[MIM:260370]. This autosomal recessive disorder is characterized by absence or hypoplasia of pancreas, leading to early-onset insulin-dependent diabetes mellitus. This was found in a frameshift mutation that produces a truncated protein and results in a second initiation that produces a second protein that act as a dominant negative mutant.Defects in PDX1 are a cause of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853]; also known as diabetes mellitus type 2. NIDDM is characterized by an autosomal dominant mode of inheritance, onset during adulthood and insulin resistance.Defects in PDX1 are the cause of maturity-onset diabetes of the young type 4 (MODY4) [MIM:606392]; also symbolized MODY-4. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.Similarity : Belongs to the Antp homeobox family. IPF1/XlHbox-8 subfamily.Contains 1 homeobox DNA-binding domain.PDX1是一种同源框转录因子-即胰十二指肠同源异型盒基因，又称IPF-1(胰岛素促进因子)、IDX-1、IUF-1。 近年来，科学家们对PDX1从不同的角度进行了卓有成效的研究。有学者认为；PDX1是发育及胰岛素基因转录表达的关键性转录因子，即决定于前体细胞向B、A、D细胞的分化。 还有学者认为：PDX1对于肠内胚层背胰芽和腹胰芽的生长、分化起重要作用，早期表达的PDX-1对上皮的形成和分化是必需的。产品图片Overlay histogram showing Mouse spleen cells stained with bs-0923R-PE (red line). The cells were fixed with 1% paraformaldehyde (10 min). The cellswere then incubated with the antibody(bs-0923R-PE, 2ug/1x106cells)for 30 min at 22-25°C. Isotype control antibody(black line) was rabbit IgG (2ug/1x106cells) used under the same conditions. Acquisition of events were used for analysis.