PDX1胰岛素促进因子抗体（胰十二指肠同源异型盒蛋白）

本公司经销PDX1，胰岛素促进因子抗体（胰十二指肠同源异型盒蛋白），克隆类型为polyclonal，宿主来源是Rabbit，PDX1胰岛素促进因子抗体（胰十二指肠同源异型盒蛋白）可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-0923R
英文名称：Anti-PDX1
中文名称：胰岛素促进因子抗体（胰十二指肠同源异型盒蛋白）
其他名称：名PDX-1; pancreatic ａnd duodenal homeobox 1; Insulin promoter factor 1; IPF-1; Islet/duodenum homeobox-1; IDX-1; Somatostatin-transactivating factor 1; STF-1; Insulin upstream factor 1; IUF-1; Glucose-sensitive factor; GSF
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 30kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, chk
产品介绍：Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide ａnd glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. Binds preferentially the DNA motif 5＇-[CT]TAAT[TG]-3＇. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching ａnd subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell. Insulin promoter factor 1 is an islet-specific protein that activates transcription of the insulin andsomatostatin genes. It is a key regulator of islet peptide hormone expressionn ａnd also plays an essential role in pancreatic development. Mutations in this gene may be involved in several disorders of the pancreas or in diabetes mellitus. Belongs to the Antp homeobox family. IPF1/XlHbox-8 subfamily. & Contains 1 homeobox DNA-binding domain. Subcellular Location: Nucleus. Tissue Specificity: Duodenum ａnd pancreas.Function : Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide ａnd glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. Binds preferentially the DNA motif 5＇-[CT]TAAT[TG]-3＇. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching ａnd subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.Subunit : Interacts with the basic helix-loop-helix domains of TCF3（E47） ａnd NEUROD1 ａnd with HMG-I（Y）. Interacts with SPOP （By similarity）. Interacts with the methyltransferase SETD7.Subcellular Location : Nucleus.Tissue Specificity : Duodenum ａnd pancreas （Langerhans islet beta cells ａnd small subsets of endocrine non-beta-cells, at low levels in acinar cells）.Post-translational modifications : Phosphorylated by the SAPK2 pathway at high intracellular glucose concentration.DISEASE : Defects in PDX1 are a cause of pancreatic agenesis （PAC）[MIM:260370]. This autosomal recessive disorder is characterized by absence or hypoplasia of pancreas, leading to early-onset insulin-dependent diabetes mellitus. This was found in a frameshift mutation that produces a truncated protein ａnd results in a second initiation that produces a second protein that act as a dominant negative mutant.Defects in PDX1 are a cause of non-insulin-dependent diabetes mellitus （NIDDM） [MIM:125853]; also known as diabetes mellitus type 2. NIDDM is characterized by an autosomal dominant mode of inheritance, onset during adulthood ａnd insulin resistance.Defects in PDX1 are the cause of maturity-onset diabetes of the young type 4 （MODY4） [MIM:606392]; also symbolized MODY-4. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood （usually before 25 years of age）, a primary defect in insulin secretion ａnd frequent insulin-independence at the beginning of the disease.Similarity : Belongs to the Antp homeobox family. IPF1/XlHbox-8 subfamily.Contains 1 homeobox DNA-binding domain.PDX1是一种同源框转录因子-即胰十二指肠同源异型盒基因，又称IPF-1（胰岛素促进因子）、IDX-1、IUF-1。 近年来，科学家们对PDX1从不同的角度进行了卓有成效的研究。有学者认为；PDX1是发育及胰岛素基因转录表达的关键性转录因子，即决定于前体细胞向B、A、D细胞的分化。 还有学者认为：PDX1对于肠内胚层背胰芽和腹胰芽的生长、分化起重要作用，早期表达的PDX-1对上皮的形成和分化是必需的。产品图片Overlay histogram showing Mouse spleen cells stained with bs-0923R-PE （red line）. The cells were fixed with 1% paraformaldehyde （10 min）. The cellswere then incubated with the antibody（bs-0923R-PE, 2ug/1x106cells）for 30 min at 22-25°C. Isotype control antibody（black line） was rabbit IgG （2ug/1x106cells） used under the same conditions. Acquisition of events were used for analysis.