Anti-SYP p38/Synaptophysin/SAP-1突触素抗体/突触相关蛋白-1

本公司提供科研SYP p38/Synaptophysin/SAP-1突触素抗体/突触相关蛋白-1，抗体质量可靠，订购SYP p38/Synaptophysin/SAP-1突触素抗体/突触相关蛋白-1请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：突触素抗体/突触相关蛋白-1
英文名称：Anti-SYP p38/Synaptophysin/SAP-1
货号：bs-0121R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 40kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, cow, chk, hrs, pig
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity.Involvement in disease:Defects in SYP are the cause of mental retardation X-linked SYP-related (MRXSYP) . Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.Subcellular Location : Cytoplasmic vesicle > secretory vesicle > synaptic vesicle membrane. Cell junction > synapse > synaptosome.Tissue Specificity : Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype.Similarity : Contains 1 BSD domain.突触素SAP-1/SYP(Synaptophysin, FRG-4)是分布于突触囊泡膜上含量丰富的糖蛋白之一，与递质释放关系密切，并可影响突触可塑性。突触相关蛋白-1可作为神经元和神经内分泌细胞的可靠标记物用于神经系统形态、功能和发育以及相关疾病的研究。对于SAP-1的功能及其具体作用机制，尚待进一步研究。产品图片Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-SYP p38/Synaptophysin/SAP-1 Polyclonal Antibody, Unconjugated(bs-0121R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) stainingAntigen: bs-0121P, 0.2ug/100ul Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Goat-Anti-Rabbit IgG(bs-0295G-HRP) at 1: 5000; TMB(C-0024) staining; Read the data in MicroplateReader by 450nm.