Anti-phospho-TOPO II Alpha (Ser1106)磷酸化DNA拓普西异构酶Ⅱ抗体

本公司提供科研phospho-TOPO II Alpha (Ser1106)磷酸化DNA拓普西异构酶Ⅱ抗体，抗体质量可靠，订购phospho-TOPO II Alpha (Ser1106)磷酸化DNA拓普西异构酶Ⅱ抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：磷酸化DNA拓普西异构酶Ⅱ抗体
英文名称：Anti-phospho-TOPO II Alpha (Ser1106)
货号：bs-3451R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 168-172kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromsome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.