phospho-TOPO II Alpha (Ser1106)磷酸化DNA拓普西异构酶Ⅱ抗体

本公司经销phospho-TOPO II Alpha （Ser1106），磷酸化DNA拓普西异构酶Ⅱ抗体，克隆类型为polyclonal，宿主来源是Rabbit，phospho-TOPO II Alpha （Ser1106）磷酸化DNA拓普西异构酶Ⅱ抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-3451R
英文名称：Anti-phospho-TOPO II Alpha （Ser1106）
中文名称：磷酸化DNA拓普西异构酶Ⅱ抗体
其他名称：名DNA topoisomeraseⅡalpha; DNA topoisomerase 2-alpha; DNA topoisomerase II, alpha isozyme; TOP2; TP2A; TOP2A; DNA topoisomerase II 170 kD; DNA topoisomerase II alpha isozyme; DNA Topoisomerase2; TOP 2A; TopII alpha; Topo II alpha; Topoisomerase DNA II alpha 170kDa; Topoisomerase II alpha 170 kDa.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 168-172kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：This gene encodes a DNA topoisomerase, an enzyme that controls ａnd alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, ａnd the relief of torsional stress that occurs during DNA transcription ａnd replication. It catalyzes the transient breaking ａnd rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromsome 17 ａnd the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents ａnd a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.