Anti-Phospho-Lck (Tyr505)磷酸化淋巴细胞特异性蛋白酪氨酸激酶抗体

本公司提供科研Phospho-Lck (Tyr505)磷酸化淋巴细胞特异性蛋白酪氨酸激酶抗体，抗体质量可靠，订购Phospho-Lck (Tyr505)磷酸化淋巴细胞特异性蛋白酪氨酸激酶抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：磷酸化淋巴细胞特异性蛋白酪氨酸激酶抗体
英文名称：Anti-Phospho-Lck (Tyr505)
货号：bs-3255R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 56kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：Lck is a lymphoid specific cytosolic protein tyrosine kinase (PTK), which is essential for T cell development and function. It is constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors and plays a key role in T cell antigen receptor (TCR) linked signal transduction pathways. Association of the TCR with a peptide antigen bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, and thereby recruits the associated Lck to the vicinity of the TCR/CD3 complex. Lck then phosphorylates tyrosine residues within the immunoreceptor tyrosine based activation motifs (ITAMs) in the cytoplasmic tails of the TCR chains and CD3 subunits. The phosphoITAMs serve as docking sites for Src homology domain 2 (SH2) containing molecules, predominantly ZAP 70 and Syk. Only then can ZAP 70 undergo tyrosine phosphorylation, become enzymatically active and further phosphorylate downstream effector molecules. In addition, Lck contributes to signaling by other receptor molecules. Lck is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature TCR.Lck淋巴细胞特异性蛋白酪氨酸激酶，是近年来发现的一种非受体型蛋白酪氨酸激酶，存在于T淋巴细胞及其它一些非T淋巴细胞内，参与细胞的信号转导过程，在多种生理及病理过程中发挥着重要作用。