Anti-Phospho-Lck (Tyr505)磷酸化淋巴细胞特异性蛋白酪氨酸激酶抗体

本公司经销Phospho-Lck （Tyr505），磷酸化淋巴细胞特异性蛋白酪氨酸激酶抗体，克隆类型为polyclonal，宿主来源是Rabbit，Phospho-Lck （Tyr505）磷酸化淋巴细胞特异性蛋白酪氨酸激酶抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-3255R
英文名称：Anti-Phospho-Lck （Tyr505）
中文名称：磷酸化淋巴细胞特异性蛋白酪氨酸激酶抗体
其他名称：名Lck （phospho-Tyr505）;p56-LCK; Lymphocyte cell-specific protein-tyrosine kinase; LSK; T cell-specific protein-tyrosine kinase; Lck p56; LSK; Lymphocyte Specific Protein Tyrosine Kinase; Membrane associated protein tyrosine kinase; Oncogene lck; P56 LCK; p56（LSTRA） protein tyrosine kinase; p56lck; pp58 lck; pp58lck; Proto oncogene tyrosine protein kinase LCK; Protooncogene tyrosine protein kinase LCK; T cell specific protein tyrosine kinase; T lymphocyte specific protein tyrosine kinase p56lck; YT 16; YT16.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 56kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo
产品介绍：Lck is a lymphoid specific cytosolic protein tyrosine kinase （PTK）, which is essential for T cell development ａnd function. It is constitutively associated with the cytoplasmic portions of the CD4 ａnd CD8 surface receptors ａnd plays a key role in T cell antigen receptor （TCR） linked signal transduction pathways. Association of the TCR with a peptide antigen bound MHC complex facilitates the interaction of CD4 ａnd CD8 with MHC class II ａnd class I molecules, respectively, ａnd thereby recruits the associated Lck to the vicinity of the TCR/CD3 complex. Lck then phosphorylates tyrosine residues within the immunoreceptor tyrosine based activation motifs （ITAMs） in the cytoplasmic tails of the TCR chains ａnd CD3 subunits. The phosphoITAMs serve as docking sites for Src homology domain 2 （SH2） containing molecules, predominantly ZAP 70 ａnd Syk. Only then can ZAP 70 undergo tyrosine phosphorylation, become enzymatically active ａnd further phosphorylate downstream effector molecules. In addition, Lck contributes to signaling by other receptor molecules. Lck is expressed at all stages of thymocyte development ａnd is required for the regulation of maturation events that are governed by both pre-TCR ａnd mature TCR.Lck淋巴细胞特异性蛋白酪氨酸激酶，是近年来发现的一种非受体型蛋白酪氨酸激酶，存在于T淋巴细胞及其它一些非T淋巴细胞内，参与细胞的信号转导过程，在多种生理及病理过程中发挥着重要作用。