Anti-phospho-KLF5(Ser275)磷酸化KLF5抗体

本公司提供科研phospho-KLF5(Ser275)磷酸化KLF5抗体，抗体质量可靠，订购phospho-KLF5(Ser275)磷酸化KLF5抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：磷酸化KLF5抗体
英文名称：Anti-phospho-KLF5(Ser275)
货号：bs-2020R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 50kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, hrs, cow, Rb, pig, dog
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：Krüppel-like factors (KLFs) zinc finger-containing transcription factors with regulatory functions in cell growth, proliferation, differentiation, and embryogenesis. KLF5, (also known as BTEB2 and IKLF), is essential for mouse embryo development. KLF5 activates many genes during cardiovascular remodeling, including PDGFa/b, Egr-1, PAI-1, iNOS, and VEGF receptors, making KLF a potential therapeutic target for cardiovascular disease. KLF5 also plays a role in angiogenesis and in development of several tumor types including breast, prostate, bladder, colon, esophagus, and skin. KLF5 is closely related to other of the KLF family members. However, KLF5 and KLF4 exhibit opposite effects on regulation of gene transcription, despite binding to similar, if not identical, cis-acting DNA sequences. In addition, KLF4 and 5 exert contrasting effects on cell proliferation in many instances; while KLF4 is an inhibitor of cell growth, KLF5 stimulates proliferation. KLF5 protein is enriched in intestinal tissue.