Anti-DUSP6/MKP-3双特异性蛋白磷酸酶6/丝裂原活化蛋白激酶磷酸酶3抗体

本公司提供科研DUSP6/MKP-3双特异性蛋白磷酸酶6/丝裂原活化蛋白激酶磷酸酶3抗体，抗体质量可靠，订购DUSP6/MKP-3双特异性蛋白磷酸酶6/丝裂原活化蛋白激酶磷酸酶3抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：双特异性蛋白磷酸酶6/丝裂原活化蛋白激酶磷酸酶3抗体
英文名称：Anti-DUSP6/MKP-3
货号：bs-11546R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 42kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, hrs, dog, cow, Rb
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：Mitogen-activated protein (MAP) kinases are a large class of proteins involved in signal transduction pathways that are activated by a range of stimuli and mediate a number of physiological and pathological changes in the cell. Dual specificity phosphatases (DSPs) are a subclass of the protein tyrosine phosphatase (PTP) gene superfamily, which are selective for dephosphorylating critical phosphothreonine and phosphotyrosine residues within MAP kinases. DSP gene expression is induced by a host of growth factors and/or cellular stresses, thereby negatively regulating MAP kinase superfamily members including MAPK/ERK, SAPK/JNK and p38. The members of the dual-specificity phosphatase protein family include MKP-1/CL100 (3CH134), VHR, PAC1, MKP-2, hVH-3 (B23), hVH-5, MKP-3, MKP-X, and MKP-4. Human MKP-3 maps to chromosome 12q22-q23 and encodes a 381 amino acid protein that specifically inactivates members of the ERK family and is expressed in a variety of tissues with the highest levels in heart and pancreas.Function : Inactivates MAP kinases. Has a specificity for the ERK family.Subcellular Location : Cytoplasm.Similarity : Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.Contains 1 rhodanese domain.Contains 1 tyrosine-protein phosphatase domain.