Anti-MOT8/SLC16A2甲状腺激素转运蛋白/单羧酸转运蛋白7/8抗体

本公司提供科研MOT8/SLC16A2甲状腺激素转运蛋白/单羧酸转运蛋白7/8抗体，抗体质量可靠，订购MOT8/SLC16A2甲状腺激素转运蛋白/单羧酸转运蛋白7/8抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：甲状腺激素转运蛋白/单羧酸转运蛋白7/8抗体
英文名称：Anti-MOT8/SLC16A2
货号：bs-11434R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 60kDa
纯化方法：affinity purified by Protein A
交叉反应：hu
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr.Subcellular Location : Cell membrane.Tissue Specificity : Highly expressed in liver and heart.DISEASE : Defects in SLC16A2 are the cause of monocarboxylate transporter 8 deficiency (MCT8 deficiency) [MIM:300523]; also known as Allan-Herndon-Dudley syndrome (AHDS). MCT8 deficiency consists of a severe form of X-linked psychomotor retardation combined with abnormal thyroid hormone (TH) levels. Thyroid hormone deficiency can be caused by defects of hormone synthesis and action, but it has also been linked to a defect in cellular hormone transport. Affected patients are males with abnormal relative concentrations of three circulating iodothyronines, as well as severe neurological abnormalities, including global developmental delay, central hypotonia, spastic quadriplegia, dystonic movements, rotary nystagmus, and impaired gaze and hearing. Heterozygous females had a milder thyroid phenotype and no neurological defects.Similarity : Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.