MOT8/SLC16A2甲状腺激素转运蛋白/单羧酸转运蛋白7/8抗体

本公司经销MOT8/SLC16A2，甲状腺激素转运蛋白/单羧酸转运蛋白7/8抗体，克隆类型为polyclonal，宿主来源是Rabbit，MOT8/SLC16A2甲状腺激素转运蛋白/单羧酸转运蛋白7/8抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-11434R
英文名称：Anti-MOT8/SLC16A2
中文名称：甲状腺激素转运蛋白/单羧酸转运蛋白7/8抗体
其他名称：名AHDS;DXS 128;DXS 128E;DXS128;DXS128 E;DXS128E;MCT 7;MCT 8;MCT7;MCT8;Monocarboxylate transporter 7;Monocarboxylate transporter 8;MOT 8;MOT8_HUMAN;MRX 22;MRX22;SLC16 A2;SLC16A 2;SLC16A2;Solute carrier family 16 （monocarboxylic acid transporters）, member 2;Solute carrier family 16 member 2;Solute carrier family 16, member 2 （monocarboxylic acid transporter 8）;Solute carrier family 16, member 2 （thyroid hormone transporter）;Solute carrier family 16, member 2;X linked PEST containing transporter;X-linked PEST-containing transporter;XPCT.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 60kDa
纯化方法：affinity purified by Protein A
交叉反应：hu
产品介绍：Very active ａnd specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine （T4）, triiodothyronine （T3）, reverse triiodothyronine （rT3） ａnd diidothyronine. Does not transport Leu, Phe, Trp or Tyr.Subcellular Location : Cell membrane.Tissue Specificity : Highly expressed in liver ａnd heart.DISEASE : Defects in SLC16A2 are the cause of monocarboxylate transporter 8 deficiency （MCT8 deficiency） [MIM:300523]; also known as Allan-Herndon-Dudley syndrome （AHDS）. MCT8 deficiency consists of a severe form of X-linked psychomotor retardation combined with abnormal thyroid hormone （TH） levels. Thyroid hormone deficiency can be caused by defects of hormone synthesis ａnd action, but it has also been linked to a defect in cellular hormone transport. Affected patients are males with abnormal relative concentrations of three circulating iodothyronines, as well as severe neurological abnormalities, including global developmental delay, central hypotonia, spastic quadriplegia, dystonic movements, rotary nystagmus, ａnd impaired gaze ａnd hearing. Heterozygous females had a milder thyroid phenotype ａnd no neurological defects.Similarity : Belongs to the major facilitator superfamily. Monocarboxylate porter （TC 2.A.1.13） family.