化学式:C21H16F4N4O2S
MW: 464.44
溶解度:DMSO ≥93mg/mL
简述:MDV3100 (Enzalutamide)是一种雄激素受体拮抗剂。
描述:
MDV3100 (Enzalutamide) is an androgen-receptor antagonist for chemotherapy-refractory prostate cancer.[1] MDV3100 blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. It also induces tumour cell apoptosis, and has no agonist activity. [2]
参考文献:
[1] American Health & Drug Benefits 2012: 51-55
[2] Lancet 2010;375: 1437–1446
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