重组人sRANK受体,Recombinant Human sRANK Receptor_详细资料

产品信息 数量：大量规格： 20µg 规格：产品价格：￥0 规格： 20µg 产品价格：￥0 本公司代理多种品Pai耗材, 如需订购请联系24小时为您服务： 公司电话：021-61507986 手机：15601775891 Q Q：1597844312 Recombinant Human sRANK Receptor 产品编号: 310-08 别名: TNFRSF11A,ODFR (osteoclast differentiation factor receptor),ODAR (osteoclast differentiation and activation receptor),TRANCE Receptor 描述: RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic-cell-membrane protein, which by interacting with RANKL augments the ability of dendritic cells to stimulate naïve T cell proliferation and to promote the survival of RANK + T cells. RANK is also expressed in a variety of tissues including skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. The RANK/RANKL interaction is important in the regulation of osteoclastogenesis and in dendritic-cell-mediated T cell immune responses. Impairments in RANK signaling have been implicated in the induction of expansile osteolysis and Paget disease of bone (PDB2). Recombinant human sRANK receptor is a 19.3 kDa polypeptide containing the TNFR homologous cysteine rich portion of the extracellular domain of RANK receptor (175 amino acid residues). 氨基酸序列: MQIAPPCTSE KHYEHLGRCC NKCEPGKYMS SKCTTTSDSV CLPCGPDEYL DSWNEEDKCL LHKVCDTGKA LVAVVAGNST TPRRCACTAG YHWSQDCECC RRNTECAPGL GAQHPLQLNK DTVCKPCLAG YFSDAFSSTD KCRPWTNCTF LGKRVEHHGT EKSDAVCSSS LPARK 来源: E.coli 纯度: Greater than 98% by SDS-PAGE gel and HPLC analyses. 生物活性: Determined by its ability to inhibit sRANKL induced NFkappaB in RAW264.7 cells in the absence of any cross-linking. The expected for this effect in the presence of 15ng/ml of recombinant sRANKL, is 30-50 ng/ml. 温馨提示：不可用于临床ZL。

规格：		产品价格：	￥0
规格：	20µg	产品价格：	￥0

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重组人sRANK受体,Recombinant Human sRANK Receptor

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