INO-1001、CAS号: 3544-24-9

 INO-1001的产品信息
英文名称：INO-1001，请联系客服QQ：1443869017获知  的库存和报价。
上海赛鑫生物技术有限公司 供应美国原装进口：INO-1001
所属分类：现货> -20摄氏度低温储备>PARP YZ剂  
别名：N/A
分子式：C₇H₈N₂O
分子量：136.15
CAS号：3544-24-9
物质化学性质：
 生物活性INO-1001 is an isoindolinone derivative and potent inhibitor of the nuclear enzyme PARP (poly (ADP-ribose) polymerase) with chemosensitization and radiosensitization properties^[1,2].  INO-1001 inhibits PARP, which may result in inhibition of tumor cell DNA repair mechanisms and, so, tumor cell resistance to chemotherapy and radiation therapy. PARP enzymes are activated by DNA breaks and have been implicated in the repair of DNA single-strand breaks (SSB).  In addition,INO-1001 improves the recovery of myocardial and endothelial function after hypothermic cardiac arrest and reduces pulmonary injury associated with extracorporal circulation. ^[3,4,5]参考文献AZD1480Tivozanib (AV-951)JNJ 26854165