Chk2 Inhibitor II hydrate - ≥98% (HPLC) Sigma C3742_详细资料

产品信息

英文名： Chk2 Inhibitor II hydrat CAS号： 516480-79-8 供应商：前尘生物保存条件： 2-8°C 数量：大量规格： 5MG

     Chk2 Inhibitor II hydrate - ≥98% (HPLC) (Sigma)
Synonym: 2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide hydrate
  Linear Formula: C₂₀H₁₄ClN₃O₂· xH₂O
  Molecular Weight: 363.80 (anhydrous basis)
  CAS Number: 516480-79-8（anhydrous）
Description

Biochem/physiol Actions Chk2 Inhibitor II is a checkpoint kinase 2 inhibitor, which controls the p53 response to DNA breaks induced by radiation, leading to apoptosis. Protection of T-cells from apoptosis implies use as an adjuvant for radiation therapy in cancer. IC₅₀= 15 nM; K_i= 37 nM. Chk2 Inhibitor II shows 1000-fold greater selectivity for the Chk2 serine/threonine kinase than for the Cdk1/B and CK1 kinases (for which IC₅₀= 12 μM and 17 μM, respectively). Chk2 Inhibitor II weakly inhibits a panel of 31 other kinases (<25% inhibition at a concentration of 10 μM and prevents apoptosis of human CD4+ and CD8+ T-cells subjected to ionizing radiation (EC₅₀= 3 μM and 7.6 μM, respectively).

性质

assay ≥98% (HPLC)

form solid

color off-white to tan

solubility DMSO: >10 mg/mL

storage temp. 2-8°C

产品信息

产地产品名称产品货号规格目录价

Sigma Chk2 Inhibitor II hydrat C3742 5MG 1,804.14

上海前尘生物科技有限公司，是一家专注于生命科学和生物技术领域的高新科技企业。是国内代理，销售，研发为一体的生物技术公司。为全国各科研单位提供优质的产品与服务

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assay	≥98% (HPLC)
form	solid
color	off-white to tan
solubility	DMSO: >10 mg/mL
storage temp.	2-8°C

产地	产品名称	产品货号	规格	目录价
Sigma	Chk2 Inhibitor II hydrat	C3742	5MG	1,804.14