Stemgent® Purified Mouse anti-Human CD90 Antibody

Stemgent® Purified Mouse anti-Human CD90 Antibody was screened on normal human mesenchymal stem cells (MSC) by immunocytochemistry (ICC) and flow cytometry (FC) and selected as the best CD90 antibody available for characterizing and/or isolating human mesenchymal stem cells. CD90 (also known as Thy-1) is a 25-35 kD protein that is expressed on 1-4% of human fetal liver cells, cord blood cells, and bone marrow cells¹. CD90 is one of the essential surface molecules expressed on human MSC from bone marrow and other sources^2-4. Activation of Thy-1 has been reported to promote T cell activation. It also affects numerous nonimmunologic biological processes, including cellular adhesion, neurite outgrowth, tumor growth, migration, and cell death⁵.

1. Craig, W., Kay, R., Cutler, R.L., Lansdorp, P.M. (1993) Expression of Thy-1 on Human Hematopoietic Progenitor Cells. J. Exp. Med. 177: 1331-1342.
2. Pittenger, M.F., Mackay, A.M., Beck, S.C., Jaiswal, R.K., Douglas, R., Mosca, J.D., Moorman, M.A., Simonetti, D.W., Craig, S., Marshak, D.R. (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284: 143-7.
3. Lee, R.H., Kim, B., Choi, I., Kim, H., Choi, H.S., Suh, K., Bae, Y.C., Jung, J.S. (2004) Characterization and expression analysis of mesenchymal stem cells from human bone marrow and adipose tissue. Cell Physiol Biochem 14: 311-324.
4. Dvorakova, J., Hruba, A., Velebny, V., Kubala, L. (2008) Isolation and characterization of mesenchymal stem cell population entrapped in bone marrow collection sets. Cell Biology International 32: 1116-1125.
5. Rege, T.A., Hagood, J.S. (2006) Thy-1 as a regulator of cell-cell and cell-matrix interactions in axon regeneration, apoptosis, adhesion, migration, cancer, and fibrosis. The FASEB Journal Vol. 20: 1045-1054.