Stemgent® DyLight™ 488 Mouse anti-Mouse/Human SSEA-1 Antibody

Stemgent® DyLight™ 488 Mouse anti-Mouse/Human SSEA-1 Antibody was screened on the mouse embryonic stem cell line R1 using immunofluorescent staining and flow cytometry (FC), and selected as the best conjugated anti-SSEA-1 antibody available for researchers needing to demonstrate mouse ES/iPS cells pluripotency. The MC-480 antibody reacts with mouse and human stage-specific embryonic antigen-1 (SSEA-1), an antigenic epitope defined as a Lewis X carbohydrate structure. It is expressed on murine embryonal carcinoma cells (EC), murine embryonic stem cells (ES), and murine and human germ cells. It is widely used as a positive surface marker for mouse undifferentiated stem cells and a negative surface marker for human undifferentiated stem cells. Expression is down-regulated following differentiation of murine EC and ES cells, while the differentiation of human EC and ES cells is accompanied by an increase in SSEA-1 expression. SSEA-1 is associated with cell adhesion, migration and differentiation.

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