Stemgent® Affinity Purified anti-Human SSEA-3 Antibody

The MC-631 monoclonal antibody reacts with Stage-Specific Embryonic Antigen-3 (SSEA-3), a carbohydrate epitope on the major ganglioside that is expressed upon the surface of human teratocarcinoma (EC) cells, human embryonic germ (EG) cells, and human embryonic stem (ES) cells. No immunoreactivity is evident with undifferentiated murine EC, ES, and EG cells. SSEA-3 can be used to characterize embryonic cells and monitor their differentiation. The expression of SSEA-3 on human ES cells is down-regulated upon differentiation. In the mouse, SSEA-3 is expressed on unfertilized eggs and preimplantation to early cleaved embryos.