中文名称:二苯基环辛炔-活性酯,氮杂二苯并环辛炔-琥珀酰亚胺酯,DBCO琥珀酰亚胺脂 英文名称:Dibenzocyclooctyne-N-hydroxysuccinimidyl ester;DBCO-NHS ester 英文别名:Dibenzocyclooctyne-N-hydroxysuccinimidyl ester; 2,5-dioxopyrrolidin-1-yl 4-(didehydrodibenzo[b,f]azocin-5(6H)-yl)-4-oxobutanoate; DBCO-NHS ester; 2,5-dioxopyrrolidin-1-yl 4-(11,12-didehydrodibenzo[b,f]azocin-5(6H)-yl)-4-oxobutanoate; DBCO-succinyl N-hydroxysuccinimidyl ester; CAS号:1353016-71-3 分子式:C23H18N2O5 分子量:402.39900 **质量:402.12200 PSA:83.99000 LogP:2.32330 结构式: Description: DBCO (Dibenzocyclooctyne) is a cycloalkyne that can reacts with azides via strain-promoted 1,3-dipolar cycloaddition in aqueous solution, a bioorthogonal reaction also termed Cu-free click reaction. This reaction has excellent selectivity and biocompatibility, such that the complimentary reagents can form covalent bonds with richly functionalized biological systems. The Cu-free click reaction has been a powerful tool in catalyst-free bioconjugation. DBCO reagents posses fast kinetcs and stability in aqueous buffer and they can be used to label azide-modified biomolecules with high specificity and reactivity.
Physical Properties: Yellow/pale-yellow solid or viscous liquid; Soluble in DMSO or DMF; Storage Conditions: Store at -20 0C, desiccate. NHS tends to hydrolyze from moisture. Avoid frequent thaw and frozen.