特别提示:包括Sulfo-DST交联剂(水溶性)在内,本公司的所有产品仅可用于科研实验,严禁用于临床YL及其他非科研用途!
产品名称:Sulfo-DST交联剂(水溶性)
英文名称:Disulfosuccinimidyltartarate
产品货号:GS4350
产品规格:50mg
分子量:548.3
储存条件:冷冻(-20℃)
概述Disulfosuccinimidyltartarate(sulfo-DST)is an analog of DST that contains sulfo-NHS esters.The negativelycharged sulfonate groups contribute enough hydrophilicityto provide water solubility for the reagent without theneed for organic
solvent dissolution before adding it to acrosslinking reaction.The conditions for conjugation areotherwise identical to DST.
NHS esters react with primary amino groups(-NH2)present on the side chain of lysine(K)residues and the N-terminus
polypeptides.The reaction proceeds efficiently in pH 7-9 buffers to form stable amide bonds and results in the release of
N-hydroxysuccinimide.Hydrolysis of the NHS ester is a competing reaction and increases with increasing pH.Hydrolysis
occurs readily in dilute protein solutions;in concentrated protein solutions,the acylation reaction is favored.
应用Reactive towards amino groups Crosslinkers formed are cleavable with 0.015 sodium periodate or other oxidizing agents.Elegant for applications in which crosslinker cleavability is desired without disturbing S-S bonds
使用说明Soluble in water.
组份50mg/bottle
技术规格 分子量 | 548.32 |
间隔臂 | 6.4? |
纯度 | >95%on TLC |
反应性基团 | NHS ester - homobifunctional cleavable |
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温馨提示:不可用于临床ZL。