现货状态: 现货 供应商: 世联博研北京公司
AIM BIOTECH是新加坡一家专注于创新性工具研发的创业型公司,其应用领域涵盖科学研究、药物开发和临床诊断范畴。AIM BIOTEC为科研市场做出的份贡献是开发出一款易于操作的、模块化的平台,该平台成功地将3D细胞培养纳入了科研人员研究工作体系之中。
AIM BIOTECH 3D细胞培养芯片概述
AIM的3D细胞培养芯片透气性好,而且用户可以通过选择不同的水凝胶,在间隔的3D和2D空间进行不同类型细胞的培养。同时可以通过对化学物浓度梯度和流体的调控很好地模拟符合用户特定需求的微环境。
3D Cell Culture Chip 3-channel design : 3D gel region flanked by 2 media channels
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Compatible with all polymerisable gels Dedicated 3D regions in AIM chips can be filled with collagen, fibrinogen & other hydrogels or Matrigel™ & other extracellular matrixes (ECM) to suit your experimental needs. The hydrogels can be used on their own or in combination with other components to form 3D microenvironments of your choice (stiffness, pH and material compositions). |
Gas exchange One of the key advantages of PDMS chips is the material's gas permeability, which enables cells cultured within PDMS devices to 'breathe'. However, PDMS absorbs hydrophobic molecules from solution, making it unsuitable for studies investigating hydrophobic drugs, chemicals or biological molecules. |
Optically clear AIM chips are made from polymers with an excellent light transmittance rate of 92%. You can visualise your experiments with phase contrast, epifluorescence, 2-photon and confocal microscopy. | Endothelial cell monolayer in 2D channel forming a vertical wall on collagen gel (confocal) | Angiogenic sprouts in collagen gel (confocal) |
Enables monotypic or organotypic co-culture models Different cell types can be cultured together in the same channel or compartmentalised into different channels, allowing users to design models to represent different biological systems. Future AIM chips will have more 3D & 2D channel designs to cater to your needs. |
Enables the control of interstitial flow across the 3D region The interstitial flow across the 3D hydrogel can be controlled by setting up a pressure gradient between the flanking channels. This can be achieved by having a larger media volume in one media channel than the other, or by setting shear flow regimes that establish a pressure differential. |
Enables the control of chemical gradients across the 3D region A chemical concentration gradient can be set up across the porous 3D hydrogel easily by using a higher concentration of the chemical in a channel and allowing diffusion to take place. This feature is very useful for studies where directional cues of effectors are critical, including angiogenesis, cell migration and neurite guidance |
Sterile & ready-to-use AIM chips are individually packaged for your convenience. All chips are sterile and are ready for use right out of the package. AIM chips let you focus on your experiments, rather than on device preparation. |
Designed for rapid media exchange through vacuum aspiration with no risk of over-aspiration Due to the small culture volumes of microfluidic devices, culture media typically has to be replenished every day. Vacuum aspiration is used to remove old media before pipetting new media into the device. Media ports in AIM chips are designed with troughs to let users rapidly aspirate old media out without the risk of accidentally aspirating all the media & cells from the device. | Cross-section of media ports during aspiration. Positioning the tip in the trough prevents over-aspiration. |
The publications listed below were conducted on lab-made devices that form the basis of AIM Biotech chips. | TECHNOLOGY |
Flexcell® Chipmate Kits with AIM Biotech Microfluidic 3D Cell Culture Chips Catalog Page | AIM Biotech Protocols | Search FAQs |
Microfluidic 3D cell culture chip for running multiple assays including cell migration, monotypic or organotypic co-culture, cell invasion, and angiogenesis.
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