Product Description: PD-L1 is a ligand for program cell death 1 (PD1). PD-L1 suppresses immune response against tumor cells upon binding to PD1 receptor. PD-L1 is expressed on T and B cells, macrophages, dendritic cells, and some nonimmune cells. Antibody binding against PD-1 or PD-L1 leads to antitumor immunity.
Synonyms: Program cell death 1 ligand 1, PDCD1 ligand 1
Accession #: Q9NZQ7
Quality control: Verified by disulfide mapping and Mass Spectrometry analyses.
Purity: >95% by SDS-PAGE gel
Product Source: PD-L1 was produced in E. Coli cells transformed with human PD-L1 gene. This product is sterile and does not contain any components of animal origin.
Formulation: Sterile filtered through a 0.2 micron filter in 20 mM Tris buffer at pH8.
Usage: FOR LABORATORY RESEARCH USE ONLY.
Storage/Stability: Avoid repeated freeze-thaw cycles. 12 months at -20 C to -80 C. 1 month at 2 C to 8 C.
References:
Hamanishi, Junzo, et al. "Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer." Proceedings of the National Academy of Sciences 104.9 (2007): 3360-3365.
Lin, David Yin-wei, et al. "The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors." Proceedings of the National Academy of Sciences 105.8 (2008): 3011-3016.