北京 Peprotech Recombinant Human IL-17 价格_详细资料

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北京 Peprotech Recombinant Human IL-17 价格
Recombinant Human IL-17 （IL-17A）
Catalog Number:
200-17
Synonyms:
IL-17, CTLA-8
Description:
The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 136 amino acid chains, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory ａnd hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions ａnd in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human ａnd murine cells. Recombinant human IL-17A is a 31.3 kDa disulfide-linked homodimer of two 137 amino acid polypeptide chains.
AA Sequence:
MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRN NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel ａnd HPLC analyses.
Biological Activity:
Assay #1: The ED₅₀ as determined by the dose-dependent induction of IL-6 in primary human foreskin fibroblasts was found to be approximately 2 ng/ml.
Assay #2: Measured by its ability to induce IL-6 production by NHDF cells.

Cross Reactivity:
Mouse, Human, Cow
Research Interests:

AIDS / HIV Angiogenesis/ Cardiovascular

Immune System Inflammation

Country of Origin:
USA

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	AIDS / HIV		Angiogenesis/ Cardiovascular
	Immune System		Inflammation