PTEN (phospho Ser380/T382/T383) Polyclonal Antibody磷酸酯酶与张力蛋白同源物 (phospho Ser380/T382/T383) 多克隆抗体_详细资料

产品信息 PTEN （phosphatase and tensin homolog）was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by PTEN is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively r 【中文名称】：磷酸酯酶与张力蛋白同源物 (phospho Ser380/T382/T383) 多克隆抗体 【英语名称】：PTEN (phospho Ser380/T382/T383) Polyclonal Antibody 【产品类型】：一抗 【供应商】：Abbkine 【产品货号】：ABP55883 【产品规格】：30u/100ul/200ul 【背景资料】：PTEN （phosphatase and tensin homolog）was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by PTEN is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of PTEN is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. 蛋白别名为：PTEN; MMAC1; TEP1; Phosphatidylinositol 3; 4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; Mutated in multiple advanced cancers 1; Phosphatase and tensin homolog;基因ID为：5728；蛋白质ID:P60484 【应用类型】：WB，IHC-p，ELISA补充：的抗体稀释比例需要基于客户实验进行优化.建议的起始稀释比例如下: WB: 1:500-1:2000, IHC-p: 1:100-1:300, ELISA: 1:20000. Not yet tested in other applications. 【免疫原】：合成多肽：human PTEN around the phosphorylation site of S380/T382/T383. 【来源宿主】：兔 【反应性】：人，小鼠，大鼠 【保存建议】：厂家推荐蓝冰运输.在发货后能在-20℃保存1年.为限度的避免损失，请在打开管盖之前融化抗体并离心.我们建议使用前分装以避免反复冻融.本产品为液体形式,溶解于PBS缓冲液中，含50%甘油，0.5%BSA和0.02%叠氮化钠. 【产品说明】：点击：磷酸酯酶与张力蛋白同源物 (phospho Ser380/T382/T383) 多克隆抗体查看更详细产品说明，更多应用、储存、价格、货期等信息请致电垂询AbbkineZG区域授权总代理艾美捷科技有限公司。更多特色试剂盒、特色抗体以及特色试剂等产品评论，请点击查看每日生物评论网站。 Abbkine致力于为生命科学研究和YL发展提供的产品和技术。Abbkine设计、开发、生产并销售了一系列独特的产品，包括生命科学领域研究相关的抗体、研究试剂以及细胞功能分析产品。Abbkine的产品为科学研究中的挑战提供卓有成效的解决方案，从而为的科学家节省时间并提高研究效率。作为Abbkine的ZG区域总代理，艾美捷科技有限公司凭借丰富的专业经验，将一如既往的为ZG区域客户提供Abbkine优质的产品和技术服务。 艾美捷科技有限公司品线覆盖生物研究各个领域，主要包括：分子生物学（核酸蛋白研究工具、cDNA/RNA、转染试剂、植物组培/细胞培养、生化试剂及试剂盒），试剂药品（蛋白酶YZ剂、化合物、荧光染料/探针、动物血清）、抗体（一抗、二抗、封闭血清），蛋白及试剂盒（细胞因子/重组蛋白、细胞凋亡/代谢/损伤、表观遗传、天然免疫）等。艾美捷为您寻找并提供的产品解决方案、Z完备的物流服务、Z及时的售后服务。如果您对上述产品线感兴趣，请致电免费服务热线到艾美捷垂询相关产品信息及完整实验解决方案。现货一抗，植物Actin内参，线粒体内参抗体，性价比高内参抗体，β-Actin抗体，高质量，核内参PCNA抗体，内参抗体高质量，GAPDH抗体，β-Tubulin抗体，内参抗体高品质，植物内参Rubisco，磷酸酯酶与张力蛋白同源物 (phospho Ser380/T382/T383) 多克隆抗体PTEN (phospho Ser380/T382/T383) Polyclonal Antibody

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