Serpin A7 (also TBG/Thyroxine-binding globulin and T4-binding globulin) is a secreted 54 kDa glycoprotein, non-inhibitory member of the serpin family of proteins. It is expressed by the liver and secreted in plasma. Mutations in the SERPINA7 gene can result in a whole spectrum of deficiencies, characterized by either reduced or increased TBG levels in the serum. A deficiency in TBG result in low serum total T4 and T3 count in clinically euthyroid subjects in the presence of normal serum TSH. Over aa21-415, human serpin A7 shares 76% aa sequence identity with mouse serpin A7.
Product Introduction:
Abbreviation
TBG
Synonym
FLJ17820; Serpin A7; T4-binding globulin; TBGclade A
Cat.No
PCSL040209
Purity
>96%
Source
Serum of blood donors. Upon examination,HIV-Ab(I, II), HBsAg, HCV-Ab, TP-Ab were negative.
Character
Liquid (Dissolved in 0.05 M pH7.5 PBS, no preservatives).