GRP78/BIP/HSPA5葡萄糖调节蛋白78抗体（热休克蛋白70蛋白5）

本公司经销GRP78/BIP/HSPA5，葡萄糖调节蛋白78抗体（热休克蛋白70蛋白5），克隆类型为polyclonal，宿主来源是Rabbit，GRP78/BIP/HSPA5葡萄糖调节蛋白78抗体（热休克蛋白70蛋白5）可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-1219R
英文名称：Anti-GRP78/BIP/HSPA5
中文名称：葡萄糖调节蛋白78抗体（热休克蛋白70蛋白5）
其他名称：名glucose regulated protein 78; 78 kDa glucose regulated protein; BIP; Endoplasmic reticulum lumenal Ca2+ binding protein grp78; FLJ26106; Glucose Regulated Protein 78kDa; GRP 78; GRP78; Heat Shock 70kDa Protein 5; HSPA 5; HSPA-5; HSPA5; Immunoglobulin Heavy Chain Binding Protein; MIF2.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 78kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo
产品介绍：The 78 kDa glucose regulated protein/BiP （GRP78） belongs to the family of ~70 kDa heat shock proteins （HSP 70）. GRP78 is a resident protein of the endoplasmic reticulum （ER） ａnd may associate transiently with a variety of newly synthesized secretory ａnd membrane proteins or permanently with mutant or defective proteins that are incorrectly folded, thus preventing their export from the ER lumen. GRP78 is a highly conserved protein that is essential for cell viability. The highly conserved sequence Lys-Asp-Glu-Leu （KDEL） is present at the C terminus of GRP78 ａnd other resident ER proteins including glucose regulated protein 94 （GRP 94） ａnd protein disulfide isomerase （PDI）. The presence of carboxy terminal KDEL appears to be necessary for retention ａnd appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor. Function : Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.Subcellular Location : Endoplasmic reticulum lumen. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.DISEASE : Note=Autoantigen in rheumatoid arthritis.Similarity : Belongs to the heat shock protein 70 family.葡萄糖调节蛋白78是热休克蛋白70家族的成员之一又称：热休克蛋白70蛋白5,作为一种分子伴侣在蛋白质的折叠和转运过程及内质网应激反应中发挥重要作用.它在多种肿瘤组织中呈高表达.产品图片Antigen: bs-1219P, 0.2ug/100ul Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Goat-Anti-Rabbit IgG（bs-0295G-HRP） at 1: 5000; TMB（C-0024） staining; Read the data in MicroplateReader by 450nm.