Phospho-Tuberin/TSC2(Ser540)磷酸化结节性硬化蛋白抗体

本公司经销Phospho-Tuberin/TSC2（Ser540），磷酸化结节性硬化蛋白抗体，克隆类型为polyclonal，宿主来源是Rabbit，Phospho-Tuberin/TSC2（Ser540）磷酸化结节性硬化蛋白抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-5608R
英文名称：Anti-Phospho-Tuberin/TSC2（Ser540）
中文名称：磷酸化结节性硬化蛋白抗体
其他名称：名TSC2（phospho S540）;FLJ43106; LAM; TSC2; TSC2_HUMAN; TSC4; Tuberin; Tuberous sclerosis 2 protein.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 200kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo
产品介绍：Tuberin, or TSC2 （Tuberous sclerosis complex）, is implicated as a tumor suppressor. It may function in vesicular transport, ａnd may also play a role in the regulation of cell growth arrest ａnd in the regulation of transcription mediated by steroid receptors. Interaction between hamartin （TSC1） ａnd tuberin may facilitate vesicular docking. It specifically stimulates the intrinsic GTPase activity of the Ras related protein RAP1A ａnd RAB5, suggesting a possible mechanism for its role in regulating cellular growth. Mutations in tuberin lead to constitutive activation of RAP1A in tumors. At least three isoforms of Tuberin exist.Tuberin 为180kD-220的蛋白产生于结节性硬化（TSC-2）位于染色体16的基因。结节性硬化为常染色体疾病已知为斑痣性错构瘤病其特征为广泛性发展呈良性生长，在许多组织与器官中描述为错构瘤。Tuberin被认为在GTPase活动性蛋白中起作用调节细胞内吞与作为肿瘤YZ子。Tuberin低水平广泛性表达在大多数组织中，而在皮层神经元、小脑浦肯野氏细胞、脊索运动神经元、胰岛B细胞、心肌、肾脏与皮肤的小血管中表达增加。