Peprotech 100-11 Recombinant Human IGF-1_详细资料

产品信息 美国Peprotech 100-11 Recombinant Human IGF-1 价格北京雅安达生物技术有限公司提供外包服务：单克隆抗体定制：服务内容：免疫、抗血清检测、融合、细胞建立、抗体制备、抗体纯化，欢迎来电咨询！ 美国Peprotech 100-11 Recombinant Human IGF-1 价格 Catalog Number: 100-11 Synonyms: Insulin-like Growth Factor-I, Somatamedin C, IGF-IA Description: The IGFs are mitogenic polypeptide growth factors that stimulate the proliferation ａnd survival of various cell types including muscle, bone, ａnd cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin ａnd relaxin. The IGFs are similar by structure ａnd function to insulin, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I ａnd IGF-II signal through the tyrosine kinase type I receptor （IGF-IR）, but, IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal ａnd C-terminal propeptide regions. Recombinant human IGF-I ａnd IGF-II are globular proteins containing 70 ａnd 67 amino acids, respectively, ａnd 3 intra-molecular disulfide bonds. AA Sequence: GPETLCGAEL VDALQFVCGD RGFYFNKPTG YGSSSRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPAKSA Source: E.coli Purity: Greater than 98% by SDS-PAGE gel ａnd HPLC analyses. Biological Activity: The ED₅₀ was determined by a cell proliferation assay using FDC-P1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 10⁵ units/mg. Cross Reactivity: Bacteria, Chicken, Cow, Frog, Horse, Monkey, Mouse, Pig, Rat, Sheep, Tiger Salamander, Hamster, Human, N/A Research Interests: Angiogenesis/ Cardiovascular Bone, Skeletal, Cartilage Diabetes / Weight Regulation Inflammation Proliferation Wound Healing Country of Origin: USA

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Peprotech 100-11 Recombinant Human IGF-1

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	Angiogenesis/ Cardiovascular		Bone, Skeletal, Cartilage
	Diabetes / Weight Regulation		Inflammation
	Proliferation		Wound Healing